Bradley F. Boeve

Research summary

The work centers on diagnostic frameworks for late-life neurodegenerative dementias. A 2009 consensus paper on mild cognitive impairment (MCI) updated subtype definitions (amnestic vs. non-amnestic, single- vs. multi-domain) and laid out biomarker and longitudinal evidence linking MCI to Alzheimer's and other dementia trajectories [5]. The 1999 study using MRI-based hippocampal volumetry showed that smaller hippocampal volumes in older adults with MCI predicted future conversion to Alzheimer's disease, helping anchor structural imaging in early diagnosis [6]. A 2009 imaging study used serial 11C-Pittsburgh-compound-B PET together with serial MRI in normal aging, MCI, and Alzheimer's to dissociate the temporal order of amyloid accumulation from downstream neurodegeneration, supporting the now-standard sequence model of Alzheimer biomarker change [7]. In dementia with Lewy bodies (DLB), the 2005 DLB Consortium criteria revision elevated REM-sleep behavior disorder, severe neuroleptic sensitivity, and reduced striatal dopamine transporter binding to clinical features that improve diagnostic specificity [3], and a 2017 update added MIBG myocardial scintigraphy and refined the weighting of supportive features, modifying pathology criteria to incorporate Alzheimer co-pathology [4]. In frontotemporal dementia, the 2011 international revised criteria for the behavioral variant (bvFTD) showed improved sensitivity over the 1998 criteria when retrospectively applied to autopsy-confirmed cases, with a tiered "possible / probable / definite" structure [1]. The 2011 classification of primary progressive aphasia and its three variants (nonfluent/agrammatic, semantic, logopenic) standardized clinical–neuroimaging definitions and improved comparability across research cohorts [2]. Together the works define the diagnostic infrastructure that distinguishes Alzheimer's, DLB, and frontotemporal syndromes during life, using a combination of clinical criteria, structural MRI, and molecular imaging.

Recent publications

1. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia2011 · Brain · 5208 citationsDOI
2. Classification of primary progressive aphasia and its variants2011 · Neurology · 5053 citationsDOI
3. Diagnosis and management of dementia with Lewy bodies2005 · Neurology · 5049 citationsDOI
4. Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS2011 · Neuron · 4943 citationsDOI
5. Diagnosis and management of dementia with Lewy bodies2017 · Neurology · 4362 citationsDOI
6. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 172006 · Nature · 2092 citationsDOI
7. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease2011 · Nature Genetics · 2005 citationsDOI
8. Mild Cognitive Impairment2009 · Archives of Neurology · 1429 citationsDOI
9. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment1999 · Neurology · 1402 citationsDOI
10. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease2009 · Brain · 1083 citationsDOI

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Email Bradley F. Boeve 6-12 months before your application deadline. Read several recent papers and reference specific work in your message. Use our how to email a Japanese professor guide for the proven email structure.

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External profiles

• ORCID: https://orcid.org/0000-0002-4153-8187
• OpenAlex: openalex.org

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