Research summary
Framingham Heart Study-based cardiovascular epidemiology organises this corpus. The 1998 Circulation paper used 12-year follow-up of 2,489 men and 2,856 women aged 30–74 to associate JNC-V blood-pressure and NCEP cholesterol categories with coronary heart disease (CHD) risk, incorporating them into prediction algorithms, and compared the discrimination of this categorical approach with non-categorical prediction functions; 383 male and 227 female CHD events occurred [1]. The 1990 NEJM paper used echocardiographically determined left ventricular mass in 3,220 Framingham subjects aged 40+ free of clinically apparent cardiovascular disease to relate LV mass to incidence of cardiovascular disease, cardiovascular mortality, and all-cause mortality, characterising LV hypertrophy as a precursor of morbidity and mortality non-invasively [2]. The 1998 Circulation paper on atrial fibrillation followed Framingham subjects aged 55–94 for 40 years and identified 296 men and 325 women (mean ages 74 and 76) who developed AF; pooled logistic regression adjusted for age, hypertension, smoking, diabetes, LV hypertrophy, MI, congestive heart failure, and valvular disease tested whether AF carries excess mortality independent of these conditions [4]. The 2002 NEJM obesity-and-heart-failure paper followed 5,881 Framingham participants (mean age 55, 54% women) for a mean 14 years using Cox proportional-hazards models to evaluate BMI as both a continuous and a categorical variable (normal, overweight, obese) in relation to incident heart failure, testing whether overweight and lesser obesity, not only extreme obesity, increase risk [5]. The 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk represents the cardiology-society guideline output [3]. Together the papers chart a coherent epidemiological programme: developing categorical risk-factor-based CHD prediction algorithms [1], establishing echocardiographic LV mass as a prognostic marker [2], quantifying AF-attributable excess mortality [4], extending heart-failure risk to overweight and moderate obesity [5], and contributing to consensus risk-assessment guidelines [3].
Recent publications
- Prediction of Coronary Heart Disease Using Risk Factor CategoriesDOI
- 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in AdultsDOI
- Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart StudyDOI
- 2013 ACC/AHA Guideline on the Assessment of Cardiovascular RiskDOI
- Impact of Atrial Fibrillation on the Risk of DeathDOI
- 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in AdultsDOI
- 2013 ACC/AHA Guideline on the Assessment of Cardiovascular RiskDOI
- Third universal definition of myocardial infarctionDOI
- Obesity and the Risk of Heart FailureDOI
- Third Universal Definition of Myocardial InfarctionDOI
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External profiles
- ORCID: https://orcid.org/0000-0003-1843-8724
- OpenAlex: openalex.org
Profile compiled from public sources (Researchmap, OpenAlex, The University of Tokyo faculty directory). Last refreshed 2026-05. Report incorrect information.