Research summary
Cardiovascular epidemiology, physical-activity measurement, and endocrine-disrupting chemicals organise this corpus. The 1993 Compendium of Physical Activities paper introduces a five-digit coding scheme that classifies physical activity by purpose (sports, occupation, self-care), specific activity type, and intensity expressed as the ratio of work to resting metabolic rate (METs), supporting estimation of energy expenditure in kilocalories or kilocalories per kg of body weight and enhancing cross-study comparability of self-reported activity [2]. The 2000 update extends and revises the Compendium with new activity codes and updated MET intensities, retaining the same conceptual scheme [1]. The 1993 paper evaluates 10 commonly used physical-activity questionnaires in 78 men and women aged 20–59 with varying activity habits, finding high one-month reliability for most questionnaires (but lower for last-week/last-month versions and lower longer-term test-retest), examining validity against treadmill performance, vital capacity, body fatness, 14×4-week activity histories, and 14×2-day accelerometer readings, and noting that no questionnaire correlated with the accelerometer measure [5]. The 1989 Circulation HDL-cholesterol-and-CVD paper revisits the British Regional Heart Study finding that covariate adjustment eliminated most of the inverse HDL-CHD association by re-analysing FHS, LRCF, CPPT, and MRFIT data with proportional-hazards adjustment for age, blood pressure, smoking, BMI, and LDL-C [3]. The 1989 NEJM paper followed 350,977 men aged 35–57 without prior MI or current diabetes treatment in MRFIT screening for six years and used proportional-hazards regression to relate serum total cholesterol to stroke mortality, finding a roughly three-fold higher six-year risk of death from intracranial haemorrhage in men with high serum cholesterol after adjustment for age, smoking, diastolic blood pressure, and race/ethnicity [6]. The 2012 Endocrine Reviews paper on endocrine-disrupting chemicals introduces low-dose effects (those in the range of human exposures or below traditional toxicological test doses) and nonmonotonic dose responses, reviews mechanistic data, and uses a weight-of-evidence approach to analyse five EDC examples, challenging the 'dose makes the poison' dogma [4].
Recent publications
- Compendium of Physical Activities: an update of activity codes and MET intensitiesDOI
- Compendium of Physical Activities: classification of energy costs of human physical activitiesDOI
- High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.DOI
- Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose ResponsesDOI
- A questionnaire for the assessment of leisure time physical activitiesDOI
- Cardia: study design, recruitment, and some characteristics of the examined subjectsDOI
- A simultaneous evaluation of 10 commonly used physical activity questionnairesDOI
- Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysisDOI
- Carbohydrates, dietary fiber, and incident type 2 diabetes in older womenDOI
- Serum Cholesterol Levels and Six-Year Mortality from Stroke in 350,977 Men Screened for the Multiple Risk Factor Intervention TrialDOI
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Email David R. Jacobs 6-12 months before your application deadline. Read several recent papers and reference specific work in your message. Use our how to email a Japanese professor guide for the proven email structure.
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External profiles
- ORCID: https://orcid.org/0000-0002-7232-0543
- OpenAlex: openalex.org
Profile compiled from public sources (Researchmap, OpenAlex, Nagoya University faculty directory). Last refreshed 2026-05. Report incorrect information.