Research summary
Contributions sit within prospective-cohort nutritional epidemiology of cardiometabolic disease, drawing on the Health Professionals Follow-up Study (HPFS) and Nurses' Health Study (NHS). A 131-item semiquantitative food frequency questionnaire was validated by repeat mailing to a sample of 127 men from the 51,529-man HPFS cohort at a one-year interval, with two one-week diet records spaced six months apart; energy-adjusted nutrient intraclass correlation coefficients ranged from 0.47 (vitamin E without supplements) to 0.80 (vitamin C with supplements) [3]. In the same cohort followed for four years, plasma vitamin E intake was related to incident coronary heart disease, framed by the LDL-oxidation hypothesis of atherogenesis [2]. Across three cohorts of 120,877 women and men followed in four-year intervals from 1986/1991 onward, specific dietary and lifestyle factors were related to long-term weight change with simultaneous multivariable adjustment for age, baseline BMI, and other lifestyle factors [1]. In 51,529 men aged 40-75 in 1986, biennial questionnaires were used to relate obesity, fat distribution, and weight gain to incident NIDDM during 5 years of follow-up (272 cases), controlling for age [5]. Among 84,129 NHS women free of cardiovascular disease, cancer, and diabetes at baseline in 1980, low-risk lifestyle composites (non-smoking, BMI, diet, physical activity) were related to 1,128 major coronary events over 14 years [6]; in 80,082 NHS women aged 34-59 in 1980 with updated dietary information, the type of dietary fat (particularly trans unsaturated fat) was related to 939 cases of nonfatal MI or coronary death over 14 years [7]. A 10-year follow-up of NHS women and HPFS men quantified the association of BMI categories with diabetes, gallstones, hypertension, heart disease, and stroke, with ~20-fold increased diabetes incidence at BMI >=35 [8]. A JAMA review weighed fish-intake cardiovascular benefits against methylmercury, dioxin, and PCB risks using MEDLINE and meta-analytic synthesis [4]. Methodologically the work is repeated-measures dietary assessment in long-running cohorts with multivariable Cox regression.
Recent publications
- Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and MenDOI
- Vitamin E Consumption and the Risk of Coronary Heart Disease in MenDOI
- Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol useDOI
- Reproducibility and Validity of an Expanded Self-Administered Semiquantitative Food Frequency Questionnaire among Male Health ProfessionalsDOI
- Fish Intake, Contaminants, and Human HealthDOI
- Alternative Dietary Indices Both Strongly Predict Risk of Chronic DiseaseDOI
- Obesity, Fat Distribution, and Weight Gain as Risk Factors for Clinical Diabetes in MenDOI
- Primary Prevention of Coronary Heart Disease in Women through Diet and LifestyleDOI
- Dietary Fat Intake and the Risk of Coronary Heart Disease in WomenDOI
- Impact of Overweight on the Risk of Developing Common Chronic Diseases During a 10-Year PeriodDOI
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External profiles
- ORCID: https://orcid.org/0000-0002-1402-7250
- OpenAlex: openalex.org
Profile compiled from public sources (Researchmap, OpenAlex, Osaka University faculty directory). Last refreshed 2026-05. Report incorrect information.