Research summary
In the early postnatal retina, VEGF-A controls angiogenic sprouting by guiding filopodial extension from endothelial tip cells positioned at vascular sprout tips; tip cells respond to VEGF-A only by guided migration while the proliferative response occurs in sprout stalks, splitting morphogenesis into two coupled tip/stalk roles [1]. A dural lymphatic vascular network was identified in the mouse meninges that absorbs cerebrospinal fluid from the adjacent subarachnoid space and brain interstitial fluid via the glymphatic system, transporting fluid to deep cervical lymph nodes through foramina at the skull base; a transgenic VEGF-C/D-trap mouse displayed complete dural lymphatic aplasia, supporting a role in CNS fluid drainage [2]. In situ hybridization for the human FLT4 (VEGFR-3) gene during mouse embryogenesis and in adult human tissues showed early expression in head mesenchyme angioblasts, cardinal vein and extraembryonal allantois at 8.5 days p.c., decoration of venous and presumptive lymphatic endothelia at 12.5 days p.c. (with arterial endothelia negative), and later restriction to lymphatic endothelia, supporting FLT4 as a lymphatic endothelial marker [3].
Recent publications
- VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodiaDOI
- A dural lymphatic vascular system that drains brain interstitial fluid and macromoleculesDOI
- Molecular regulation of angiogenesis and lymphangiogenesisDOI
- Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasisDOI
- A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.DOI
- Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.DOI
- Lymphangiogenesis: Molecular Mechanisms and Future PromiseDOI
- Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumourDOI
- Control of vascular morphogenesis and homeostasis through the angiopoietin鈥揟ie systemDOI
- Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veinsDOI
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External profiles
- ORCID: https://orcid.org/0000-0002-7331-0902
- OpenAlex: openalex.org
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