Research summary
The Women's Health Initiative randomly assigned 36,282 postmenopausal women aged 50-79 to 1000 mg elemental calcium as calcium carbonate plus 400 IU vitamin D3 daily or placebo and followed them for 7 years, measuring hip-bone density at three WHI centres alongside fracture incidence [1]. Cardiovascular event rates in 498 women with systemic lupus erythematosus at the University of Pittsburgh Medical Center (1980-1993, 3522 person-years) were age-stratified and compared with 2208 Framingham Offspring women over the same period using age-specific rate ratios [2]. In the SMART trial, six biomarkers (hsCRP, IL-6, amyloid A, amyloid P, D-dimer, and prothrombin fragment 1+2) were measured to relate tissue-factor pathway activation and inflammation to mortality after antiretroviral interruption [3]. The integrated WHI menopausal hormone therapy report combined 27,347 postmenopausal women in two trials of CEE+MPA versus placebo (intact uterus) and CEE alone versus placebo (prior hysterectomy) with extended postintervention follow-up [4]. The Cardiovascular Health Study followed 5201 adults >=65 years between 1989 and 1993 with annual examinations including carotid ultrasound, pulmonary function, ECG, and echocardiography to identify atrial-fibrillation risk factors via Cox modelling [5]. A demographically and behaviourally matched cohort of HIV-positive and HIV-negative individuals was compared for acute MI risk adjusting for Framingham risk factors [6]. Laparoscopic Roux-en-Y gastric bypass was evaluated for T2DM improvement over four years [7]. A nested case-control analysis within MRFIT (98 MI cases, 148 CHD deaths, 491 controls) related C-reactive protein, alpha1-acid glycoprotein, and albumin to CHD mortality over up to 17 years of follow-up [8]. Cardiometabolic multimorbidity mortality was quantified in 689,300 participants across 91 cohorts in the Emerging Risk Factors Collaboration and 499,808 UK Biobank participants [9].
Recent publications
- The cardiovascular health study: Design and rationaleDOI
- Calcium plus Vitamin D Supplementation and the Risk of FracturesDOI
- Age-specific Incidence Rates of Myocardial Infarction and Angina in Women with Systemic Lupus Erythematosus: Comparison with the Framingham StudyDOI
- Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV InfectionDOI
- Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women鈥檚 Health Initiative Randomized TrialsDOI
- Incidence of and Risk Factors for Atrial Fibrillation in Older AdultsDOI
- HIV Infection and the Risk of Acute Myocardial InfarctionDOI
- Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes MellitusDOI
- Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control StudyDOI
- Association of Cardiometabolic Multimorbidity With MortalityDOI
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External profiles
- ORCID: https://orcid.org/0000-0002-7148-8416
- OpenAlex: openalex.org
Profile compiled from public sources (Researchmap, OpenAlex, Keio University faculty directory). Last refreshed 2026-05. Report incorrect information.