Research summary
Schizophrenia epidemiology and clinical neuroscience form the central focus. A meta-analysis of structural MRI studies in schizophrenia, using random-effects modelling, quantified regional brain-volume differences between patients and comparison subjects across cortical, subcortical, and ventricular regions, with regression analyses examining sex effects [1]. A historical and meta-analytic review of obstetric complications synthesised prospective population-based studies and confirmed a modest but consistent association between adverse perinatal events and adult schizophrenia [6]. Prospective follow-up of a birth cohort (N=761) showed that self-reported delusional beliefs and hallucinatory experiences at age 11 predicted schizophreniform disorder at age 26, the first direct longitudinal link between childhood psychotic symptoms and adult phenotype [5]. A separate longitudinal cohort study reported that adolescent cannabis use predicted adult psychosis risk [4]. A pragmatic, noncommercially funded, multisite randomised controlled trial compared second- versus first-generation antipsychotics across 12, 26, and 56 weeks with blind assessment, testing whether atypical antipsychotics (excluding clozapine) improved quality of life across one year in patients requiring a medication change [7]. The clinical-trials portfolio also includes a double-blind randomised trial in hormone-refractory metastatic prostate carcinoma in which zoledronic acid 4 mg every three weeks reduced skeletal-related events compared with placebo across 643 patients followed for 15 months [2], and a gene-targeting study in which IL-7 inactivation produced peripheral lymphopenia, a pro-B to pre-B block, and 10–20-fold reductions in thymic and splenic cellularity, identifying IL-7 as a nonredundant cytokine for lymphopoiesis [3].
Recent publications
- Large recurrent microdeletions associated with schizophreniaDOI
- Common variants conferring risk of schizophreniaDOI
- Meta-Analysis of Regional Brain Volumes in SchizophreniaDOI
- A Randomized, Placebo-Controlled Trial of Zoledronic Acid in Patients With Hormone-Refractory Metastatic Prostate CarcinomaDOI
- Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.DOI
- Moderation of the Effect of Adolescent-Onset Cannabis Use on Adult Psychosis by a Functional Polymorphism in the Catechol-O-Methyltransferase Gene: Longitudinal Evidence of a Gene X Environment InteractionDOI
- Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective studyDOI
- Children's Self-Reported Psychotic Symptoms and Adult Schizophreniform DisorderDOI
- Obstetric Complications and Schizophrenia: Historical and Meta-Analytic ReviewDOI
- Randomized Controlled Trial of the Effect on Quality of Life of Second- vs First-Generation Antipsychotic Drugs in SchizophreniaDOI
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External profiles
- ORCID: https://orcid.org/0000-0003-0829-0519
- OpenAlex: openalex.org
Profile compiled from public sources (Researchmap, OpenAlex, The University of Tokyo faculty directory). Last refreshed 2026-05. Report incorrect information.